| ncRNA name | Sin1 shRNA |
| ncRNA Category | shRNA |
| Disease name | retinopathy of prematurity (ROP) |
| Species | Homo sapiens |
| Tissues/Cell_line | human RPE cell line ARPE-19 |
| Methods | shRNA knockdown, MTT assay, BrdU incorporation assay, transwell assay, qRT-PCR, ELISA, Western blot |
| Expression pattern | associated |
| Functional description | Gremlin promotes RPE cell proliferation, migration and VEGF production possibly via activating VEGFR2-Akt-mTORC2 signaling. Rictor or Sin1 knockdown significantly inhibited gremlin-induced cell proliferation, migration and VEGF production. |
| PubMed ID | 27894090 |
| Year | 2017 |
| Title | Gremlin promotes retinal pigmentation epithelial (RPE) cell proliferation, migration and VEGF production via activating VEGFR2-Akt-mTORC2 signaling. |
| Drug-related ncRNA | NA |
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